Branaplam (hydrochloride) [CAS 1562338-39-9]
Branaplam (hydrochloride) [CAS 1562338-39-9]
SKU:QM-0155418-01
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Product Details
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Description
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2].
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CAS Number
[1562338-39-9]
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Molecular Formula
C22H28ClN5O2
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Molecular Weight
429.94
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Smiles
OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3.Cl
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Target
DNA/RNA Synthesis; Potassium Channel
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Concentration
10mM
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Purity
99.43
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Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 200 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Branaplam (hydrochloride) [CAS 1562338-39-9]
Branaplam (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.