Breast cancer targeting peptide 18–4 [CAS 1332850-08-4]

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Description
Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a Kd of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively[1].
CAS Number
[1332850-08-4]
Molecular Formula
C63H89N15O15
Molecular Weight
1296.47
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@@H](CCCC)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O
Target
Microtubule/Tubulin
Shipping Conditions
Room temperature

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Breast cancer targeting peptide 18–4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.