Britannin [CAS 33627-28-0]
Britannin [CAS 33627-28-0]
SKU:QM-0165184-01
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Product Details
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Description
Britannin is an NLRP3 inhibitor with an IC50 of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics[1][2][3][4][5].
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CAS Number
[33627-28-0]
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Molecular Formula
C19H26O7
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Molecular Weight
366.41
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Smiles
C[C@]12[C@@]([C@@H](C[C@@](O3)([H])[C@](C(C3=O)=C)([H])[C@@H]2OC(C)=O)C)([H])[C@@H](OC(C)=O)C[C@@H]1O
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Target
Apoptosis; Autophagy; NOD-like Receptor (NLR) ; Pyroptosis
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Isoform
NLRP3
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Concentration
10mM
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Purity
99.93
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Britannin [CAS 33627-28-0]
Britannin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.