C6 Urea Ceramide [CAS 486991-52-0]
C6 Urea Ceramide [CAS 486991-52-0]
SKU:QM-0096560-01
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Product Details
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Description
C6 Urea Ceramide (Cer (d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells. C6 Urea Ceramide (5-10 μM) inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated β-catenin levels in HT-29 and HCT116 cells, and induces colocalization of β-catenin with the 20S proteasome. C6 Urea Ceramide (1.25, 2.5, and 5 mg/kg) reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.
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CAS Number
[486991-52-0]
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Molecular Formula
C25H50N2O3
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Molecular Weight
426.68
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Smiles
CCCCCCNC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
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Target
Apoptosis; Autophagy; Ceramidase; β-catenin
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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C6 Urea Ceramide [CAS 486991-52-0]
C6 Urea Ceramide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.