Cabozantinib (Standard) [CAS 849217-68-1]
Cabozantinib (Standard) [CAS 849217-68-1]
SKU:QM-0084906-01
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Product Details
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Description
Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively) . Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2].
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CAS Number
[849217-68-1]
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Molecular Formula
C28H24FN3O5
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Molecular Weight
501.51
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Smiles
O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
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Target
Apoptosis; c-Kit; c-Met/HGFR; FLT3; Reference Standards; TAM Receptor; VEGFR
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Purity
99.33
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Storage Conditions
4°C, sealed storage, away from light and moisture
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Shipping Conditions
Room Temperature
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Cabozantinib (Standard) [CAS 849217-68-1]
Cabozantinib (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.