Canertinib (dihydrochloride) [CAS 289499-45-2]
Canertinib (dihydrochloride) [CAS 289499-45-2]
SKU:QM-0083467-01
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Product Details
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Description
Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice[1][2][3][4].
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CAS Number
[289499-45-2]
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Molecular Formula
C24H27Cl3FN5O3
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Molecular Weight
558.86
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Smiles
C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl
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Target
EGFR; Orthopoxvirus
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Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
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Purity
99.68
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Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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Canertinib (dihydrochloride) [CAS 289499-45-2]
Canertinib (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.