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CDK/HDAC-IN-2 [CAS 2580938-58-3]

CDK/HDAC-IN-2 [CAS 2580938-58-3]

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SKU:QM-0066741

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  • Description

    CDK/HDAC-IN-2 is a potent HDAC/CDK dual inhibitor with IC50 of 6.4, 0.25, 45, >1000, 8.63, 0.30, >1000 nM for HDAC1, HDAC2, HDAC3, HDAC6,8, CDK1, CDK2, CDK4,6,7, respectively. CDK/HDAC-IN-2 shows excellent antiproliferative activities. CDK/HDAC-IN-2 induces apoptosis and cell cycle arrest at G2/M phase. CDK/HDAC-IN-2 shows potent antitumor efficacy[1].

  • CAS Number

    [2580938-58-3]

  • Molecular Formula

    C25H20Cl2N6O3

  • Molecular Weight

    523.37

  • Smiles

    NC1=CC=CC=C1NC(C2=CC=C(C=C2)CNC(C3=NNC=C3NC(C4=C(C=CC=C4Cl)Cl)=O)=O)=O

  • Target

    Apoptosis; CDK; HDAC

  • Isoform

    CDK1; CDK2; CDK4; CDK6; CDK7; HDAC1; HDAC2; HDAC3; HDAC6; HDAC8

  • Solubility

    10 mM in DMSO

  • Shipping Conditions

    Room temperature

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CDK/HDAC-IN-2 [CAS 2580938-58-3]

CDK/HDAC-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.