CDK9/HDAC1/HDAC3-IN-1 [CAS 2197029-81-3]
CDK9/HDAC1/HDAC3-IN-1 [CAS 2197029-81-3]
SKU:QM-0011032
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Product Details
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Description
CDK9/HDAC1/HDAC3-IN-1 is dual-functional inhibitor of CDK9 and HDAC. CDK9/HDAC1/HDAC3-IN-1 inhibits the protein activity of CDK9/HDAC/HDAC3 with IC50 s of 0.17 μM, 1.73 μM and 1.11 μM for CDK9, HDAC1, and HDAC3, respectively. CDK9/HDAC1/HDAC3-IN-1 inhibits cancer cells by inducing cell apoptosis and cell cycle arrest in the G2/M phase, as well as tumor growth in a murine TNBC MDA-MB-231 xenograft model. CDK9/HDAC1/HDAC3-IN-1 has a broad-spectrum anti-cancer activity, such as breast cancer, cervical cancer, and liver cancer[1].
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CAS Number
[2197029-81-3]
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Molecular Formula
C24H22N8OS
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Molecular Weight
470.55
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Smiles
CNC1=NC(C)=C(S1)C2=NC(NC3=CC=C4C(C=C(C(NC5=CC=CC=C5N)=O)N4)=C3)=NC=C2
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Target
Apoptosis; CDK; HDAC
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Isoform
CDK9; HDAC1; HDAC3
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Shipping Conditions
Room temperature
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CDK9/HDAC1/HDAC3-IN-1 [CAS 2197029-81-3]
CDK9/HDAC1/HDAC3-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.