CHMFL-EGFR-202 [CAS 2089381-40-6]
CHMFL-EGFR-202 [CAS 2089381-40-6]
SKU:QM-0081337-01
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Product Details
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Description
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ～10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent "DFG-in-C-helix-out" inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines[1].
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CAS Number
[2089381-40-6]
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Molecular Formula
C25H24ClN7O2
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Molecular Weight
489.96
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Smiles
O=C(N(C1)CCC[C@H]1N2C3=NC=NC(N)=C3C(C4=CC(Cl)=C(OCC5=NC=CC=C5)C=C4)=N2)C=C
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Target
BMX Kinase; Btk; EGFR; MEK
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Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4; MEK1
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Purity
99.75
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Solubility
DMSO : ≥ 110 mg/mL
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Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Blue Ice
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CHMFL-EGFR-202 [CAS 2089381-40-6]
CHMFL-EGFR-202 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.