CHMFL-PI3KD-317 [CAS 2244992-76-3]
CHMFL-PI3KD-317 [CAS 2244992-76-3]
SKU:QM-0137586-01
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Product Details
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Description
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM) . CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells[1].
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CAS Number
[2244992-76-3]
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Molecular Formula
C21H24ClN5O3S2
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Molecular Weight
494.03
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Smiles
ClC1=C(NS(=O)(C2=CC(C)=CC=C2)=O)C=C(C3=C(C)N=C(NC([C@H](C(C)C)N)=O)S3)C=N1
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Target
PI3K
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Isoform
PI3KC2β; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
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Purity
98.04
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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CHMFL-PI3KD-317 [CAS 2244992-76-3]
CHMFL-PI3KD-317 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.