Cholesteryl sulfate (sodium) [CAS 2864-50-8]
Cholesteryl sulfate (sodium) [CAS 2864-50-8]
SKU:QM-0137007-01
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Product Details
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Description
Cholesteryl sulfate sodium is an orally available, NPC2-targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC50=50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride , while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation[1][2][3].
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CAS Number
[2864-50-8]
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Molecular Formula
C27H45NaO4S
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Molecular Weight
488.7
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Smiles
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
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Target
Endogenous Metabolite
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Concentration
10mM
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Purity
99.86
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Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
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Shipping Conditions
Blue Ice
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Hazard Statement
H301, H311, H331, H341
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Precautions
H301, H311, H331, H341
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Cholesteryl sulfate (sodium) [CAS 2864-50-8]
Cholesteryl sulfate (sodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.