Cholic acid 7-sulfate-d4 [CAS 1332881-66-9]
Cholic acid 7-sulfate-d4 [CAS 1332881-66-9]
SKU:QM-0005332
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Product Details
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Description
Cholic acid 7-sulfate-d4 (7-Sulfocholic acid-d4) is the deuterium labeled Cholic acid 7-sulfate. Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation[1][2].
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CAS Number
[1332881-66-9]
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Molecular Formula
C24H36D4O8S
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Molecular Weight
492.66
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Smiles
C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](OS(=O)(O)=O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
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Target
G protein-coupled Bile Acid Receptor 1; Isotope-Labeled Compounds; MHC
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Shipping Conditions
Room temperature
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Cholic acid 7-sulfate-d4 [CAS 1332881-66-9]
Cholic acid 7-sulfate-d4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.