Chromomycin A3 (Standard) [CAS 7059-24-7]
Chromomycin A3 (Standard) [CAS 7059-24-7]
SKU:QM-0049044
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Product Details
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Description
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3. This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe[1][2][3].
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CAS Number
[7059-24-7]
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Molecular Formula
C57H82O26
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Molecular Weight
1183.25
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Smiles
O=C1C2=C(C[C@H]([C@@H]1O[C@](C[C@@H](O[C@](C[C@@H](O[C@@]3([H])C[C@](O)([C@H]([C@@H](O3)C)OC(C)=O)C)[C@@H]4O)([H])O[C@@H]4C)[C@@H]5O)([H])O[C@@H]5C)[C@@H](C([C@H]([C@@H](C)O)O)=O)OC)C=C(C=C6O[C@H]7C[C@H]([C@H]([C@H](O7)C)OC(C)=O)O[C@]8([H])C[C@H]([C@H]([C@H](O8)C)OC)O)C(C(O)=C6C)=C2O
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Target
Antibiotic; Apoptosis; Bacterial; Fungal; Reference Standards
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Shipping Conditions
Room temperature
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Chromomycin A3 (Standard) [CAS 7059-24-7]
Chromomycin A3 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.