Cinrebafusp alfa [CAS 2218515-90-1]
Cinrebafusp alfa [CAS 2218515-90-1]
SKU:QM-0201924-01
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Product Details
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Description
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM) . Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research[1][2].
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CAS Number
[2218515-90-1]
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Smiles
[Cinrebafuspalfa]
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Target
EGFR; TNF Receptor
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Isoform
ErbB2/HER2; TNFRSF9/4-1BB/CD137
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Purity
98.53
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Solubility
H2O
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Storage Conditions
Store at -80°C for 2 years
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Shipping Conditions
Dry Ice
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Cinrebafusp alfa [CAS 2218515-90-1]
Cinrebafusp alfa is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.