Cl-amidine (hydrochloride) (Standard) [CAS 1373232-26-8]
Cl-amidine (hydrochloride) (Standard) [CAS 1373232-26-8]
SKU:QM-0001910
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Product Details
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Description
Cl-amidine (hydrochloride) (Standard) is the analytical standard of Cl-amidine (hydrochloride). This product is intended for research and analytical applications. Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR) -16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model[1][2][3][4][5].
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CAS Number
[1373232-26-8]
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Molecular Formula
C14H20Cl2N4O2
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Molecular Weight
347.25
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Smiles
O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
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Target
Apoptosis; MicroRNA; Protein Arginine Deiminase; Reference Standards
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Shipping Conditions
Room temperature
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Cl-amidine (hydrochloride) (Standard) [CAS 1373232-26-8]
Cl-amidine (hydrochloride) (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.