Cl-Necrostatin-1 [CAS 862377-51-3]
Cl-Necrostatin-1 [CAS 862377-51-3]
SKU:QM-0008572-01
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Product Details
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Description
Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO) . Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].
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CAS Number
[862377-51-3]
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Molecular Formula
C13H12ClN3OS
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Molecular Weight
293.77
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Smiles
O=C1N(C)C(NC1CC2=CNC3=C2C=CC=C3Cl)=S
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Target
Apoptosis; RIP kinase; TNF Receptor
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Shipping Conditions
Room temperature
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Cl-Necrostatin-1 [CAS 862377-51-3]
Cl-Necrostatin-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.