Clozapine N-oxide (dihydrochloride) [CAS 2250025-93-3]
Clozapine N-oxide (dihydrochloride) [CAS 2250025-93-3]
SKU:QM-0154442-01
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Product Details
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Description
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
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CAS Number
[2250025-93-3]
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Molecular Formula
C18H21Cl3N4O
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Molecular Weight
415.74
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Smiles
C[N+]1([O-])CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1.[H]Cl.[H]Cl
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Target
Dopamine Receptor; Drug Metabolite; mAChR
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Isoform
MAChR3; mAChR4
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Purity
99.74
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Solubility
DMSO : ≥ 200 mg/mL|H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H336
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Precautions
H301, H336
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Clozapine N-oxide (dihydrochloride) [CAS 2250025-93-3]
Clozapine N-oxide (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.