Clozapine (Standard) [CAS 5786-21-0]
Clozapine (Standard) [CAS 5786-21-0]
SKU:QM-0148523-01
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Product Details
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Description
Clozapine (Standard) is the analytical standard of Clozapine. This product is intended for research and analytical applications. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) [4].
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CAS Number
[5786-21-0]
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Molecular Formula
C18H19ClN4
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Molecular Weight
326.82
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Smiles
CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42
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Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; mAChR; Reference Standards
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Isoform
5-HT2 Receptor; mAChR1; mAChR4; α adrenergic receptor
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Purity
99.98
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Storage Conditions
4°C, sealed storage, away from light and moisture
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H351
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Precautions
H301, H351
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Clozapine (Standard) [CAS 5786-21-0]
Clozapine (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.