Coibamide A [CAS 1029227-48-2]
Coibamide A [CAS 1029227-48-2]
SKU:QM-0109397
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Product Details
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Description
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts[1][2].
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CAS Number
[1029227-48-2]
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Molecular Formula
C65H110N10O16
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Molecular Weight
1287.63
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Smiles
CC(C)[C@H](N(C)C)C(O[C@H](C(C)C)C(N(C)[C@@H](COC)C(N(C)[C@@H](CC(C)C)C(N([C@@H]1C(N([C@H](C(N([C@@](C(N[C@H](C(N([C@H](C(N[C@H](C(N([C@@H](C(O[C@@H]1C)=O)C)C)=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)C)=O)C)=O)([H])[C@@H](C)CC)C)=O)COC)C)=O)C)=O)=O)=O)=O
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Target
Apoptosis; Autophagy; VEGFR
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Isoform
VEGFR2/KDR/Flk-1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Coibamide A [CAS 1029227-48-2]
Coibamide A is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.