Columbamine (chloride) [CAS 1916-10-5]
Columbamine (chloride) [CAS 1916-10-5]
SKU:QM-0163418-01
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Product Details
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Description
Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an organic heterotetracyclic alkaloid extracted from plants. Columbamine chloride is a metabolite of Berberine. Columbamine chloride inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). Columbamine chloride induces apoptosis in cancer cells. Columbamine chloride can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study[1][2][3][4][5][6].
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CAS Number
[1916-10-5]
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Molecular Formula
C20H20ClNO4
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Molecular Weight
373.83
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Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(OC)C=C4CC3)C=C2C=C1.[Cl-]
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Target
Apoptosis; Cytochrome P450; Parasite
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Isoform
CYP3A4
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Purity
99.62
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Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Columbamine (chloride) [CAS 1916-10-5]
Columbamine (chloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.