Compstatin [CAS 206645-99-0]
Compstatin [CAS 206645-99-0]
SKU:QM-0203336-01
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Product Details
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Description
Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans) . Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].
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CAS Number
[206645-99-0]
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Molecular Formula
C66H99N23O17S2
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Molecular Weight
1550.77
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Smiles
O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CC2=CNC=N2)=O)CC3=CNC=N3)=O)=O)CC4=CNC5=CC=CC=C45)=O)CC(O)=O)=O)CCC(N)=O)=O)C(C)C)=O)C(C)C)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N)=O)[C@@H](C)O)=O
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Target
Complement System
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Purity
99.58
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Solubility
H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Compstatin [CAS 206645-99-0]
Compstatin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.