Compstatin (TFA)
Compstatin (TFA)
SKU:QM-0171839-01
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Product Details
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Description
Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans) . Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3].
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Molecular Formula
C66H99N23O17S2.xC2HF3O2
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Smiles
O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CC2=CNC=N2)=O)CC3=CNC=N3)=O)=O)CC4=CNC5=CC=CC=C45)=O)CC(O)=O)=O)CCC(N)=O)=O)C(C)C)=O)C(C)C)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N)=O)[C@@H](C)O)=O.O=C(O)C(F)(F)F.[F,Cl,Br,I]
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Target
Complement System
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Purity
99.07
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Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Compstatin (TFA)
Compstatin (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.