Copanlisib (dihydrochloride) [CAS 1402152-13-9]
Copanlisib (dihydrochloride) [CAS 1402152-13-9]
SKU:QM-0151174-01
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Product Details
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Description
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity[1].
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CAS Number
[1402152-13-9]
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Molecular Formula
C23H30Cl2N8O4
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Molecular Weight
553.44
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Smiles
O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25.[H]Cl.[H]Cl
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Target
Apoptosis; PI3K
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Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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Purity
99.55
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Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H360, H372
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Precautions
H360, H372
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Copanlisib (dihydrochloride) [CAS 1402152-13-9]
Copanlisib (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.