Crebinostat [CAS 1092061-61-4]
Crebinostat [CAS 1092061-61-4]
SKU:QM-0138998-01
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Product Details
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Description
Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhances the expression of the cAMP response element-binding protein (CREB) target gene Egr1. Crebinostat increases the density of synapsin-1 punctae along dendrites in cultured neurons. Crebinostat can modulate chromatin-mediated neuroplasticity and exhibits enhanced memory in mice[1].
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CAS Number
[1092061-61-4]
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Molecular Formula
C20H23N3O3
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Molecular Weight
353.41
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Smiles
O=C(N/N=C/C1=CC=C(C2=CC=CC=C2)C=C1)CCCCCC(NO)=O
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Target
HDAC
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Isoform
HDAC1; HDAC2; HDAC3; HDAC6
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Purity
99.79
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Crebinostat [CAS 1092061-61-4]
Crebinostat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.