CRT0066101 (dihydrochloride) [CAS 1883545-60-5]
CRT0066101 (dihydrochloride) [CAS 1883545-60-5]
SKU:QM-0077146-01
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Product Details
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Description
CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS -induced lung injury models, and has anticancer effects[1][2][3].
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CAS Number
[1883545-60-5]
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Molecular Formula
C18H24Cl2N6O
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Molecular Weight
411.33
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Smiles
OC1=CC=C(C2=CN(C)N=C2)C=C1C3=NC=CC(NC[C@H](N)CC)=N3.[H]Cl.[H]Cl
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Target
Apoptosis; Pim; PKD
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Isoform
PIM2; PKD1; PKD2; PKD3
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Purity
99.92
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Solubility
DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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CRT0066101 (dihydrochloride) [CAS 1883545-60-5]
CRT0066101 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.