D-α-Hydroxyglutaric acid (disodium) [CAS 103404-90-6]
D-α-Hydroxyglutaric acid (disodium) [CAS 103404-90-6]
SKU:QM-0079425-01
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Product Details
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Description
D-α-Hydroxyglutaric acid disodium (Disodium (R) -2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].
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CAS Number
[103404-90-6]
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Molecular Formula
C5H6Na2O5
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Molecular Weight
192.08
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Smiles
O=C(O[Na])[C@H](O)CCC(O[Na])=O
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Target
ATP Synthase; Endogenous Metabolite; mTOR; Reactive Oxygen Species (ROS)
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Isoform
Human Endogenous Metabolite
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Purity
98
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Solubility
H2O : 75 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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D-α-Hydroxyglutaric acid (disodium) [CAS 103404-90-6]
D-α-Hydroxyglutaric acid (disodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.