D-threo-PDMP (hydrochloride) [CAS 139889-62-6]
D-threo-PDMP (hydrochloride) [CAS 139889-62-6]
SKU:QM-0138880-01
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Product Details
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Description
D-threo-PDMP hydrochloride is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids (such as GM3 and GD3) on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth. D-threo-PDMP hydrochloride inhibits the synthesis of GM3, thereby reducing the adhesion ability of B16 melanoma cells and mimicking the pathological effects of hyperglycemia/TGF-β1. D-threo-PDMP hydrochloride inhibits the synthesis of GD3, thereby protecting liver cells from apoptosis induced by TNF-α. D-threo-PDMP hydrochloride can be used to study diseases related to targeted glycosphingolipid metabolism[1][2][3][4].
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CAS Number
[139889-62-6]
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Molecular Formula
C23H39ClN2O3
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Molecular Weight
427.02
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Smiles
CCCCCCCCCC(N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2)=O.Cl[H]
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Target
Glucosylceramide Synthase (GCS)
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Purity
98
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Solubility
Ethanol : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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D-threo-PDMP (hydrochloride) [CAS 139889-62-6]
D-threo-PDMP (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.