DAPI [CAS 47165-04-8]
DAPI [CAS 47165-04-8]
SKU:QM-0020500-01
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Product Details
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Description
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1]. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[2] (Ex/Em = 356/451 nm) .
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CAS Number
[47165-04-8]
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Molecular Formula
C16H15N5
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Molecular Weight
277.32
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Smiles
N=C(C1=CC=C(C2=CC3=CC=C(C(N)=N)C=C3N2)C=C1)N
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Target
DNA Stain; Sodium Channel
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Purity
98.01
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Solubility
DMSO : 9.09 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCL)
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Storage Conditions
-20°C (Powder, protect from light)
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Shipping Conditions
Blue Ice
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DAPI [CAS 47165-04-8]
DAPI is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.