DAPI (dihydrochloride) [CAS 28718-90-3]
DAPI (dihydrochloride) [CAS 28718-90-3]
SKU:QM-0160725-01
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Product Details
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Description
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1]. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment[2] (Ex/Em = 356/451 nm) .
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CAS Number
[28718-90-3]
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Molecular Formula
C16H17Cl2N5
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Molecular Weight
350.25
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Smiles
N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(C(N)=N)C=C3)N2)N.[H]Cl.[H]Cl
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Target
DNA Stain; Sodium Channel
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Purity
99.9
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Solubility
DMSO : 75 mg/mL (ultrasonic) |H2O : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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Hazard Statement
H315, H317, H335
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Precautions
H315, H317, H335
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DAPI (dihydrochloride) [CAS 28718-90-3]
DAPI (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.