DB1976 (dihydrochloride) [CAS 2369663-93-2]
DB1976 (dihydrochloride) [CAS 2369663-93-2]
SKU:QM-0076537-01
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Product Details
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Description
DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect[1][2][3].
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CAS Number
[2369663-93-2]
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Molecular Formula
C20H18Cl2N8Se
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Molecular Weight
520.28
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Smiles
N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N.[H]Cl.[H]Cl
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Target
Apoptosis
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Purity
98
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 18.33 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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DB1976 (dihydrochloride) [CAS 2369663-93-2]
DB1976 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.