Diclofensine (hydrochloride) [CAS 34041-84-4]
Diclofensine (hydrochloride) [CAS 34041-84-4]
SKU:QM-0155014-01
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Product Details
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Description
Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE) . The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM) . On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].
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CAS Number
[34041-84-4]
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Molecular Formula
C17H18Cl3NO
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Molecular Weight
358.69
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Smiles
CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1.[H]Cl
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Target
Dopamine Transporter
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Concentration
10mM
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Purity
99.79
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Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 52 mg/mL
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Diclofensine (hydrochloride) [CAS 34041-84-4]
Diclofensine (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.