Dofequidar (sesquifumarate) [CAS 158681-49-3]
Dofequidar (sesquifumarate) [CAS 158681-49-3]
SKU:QM-0099601
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Product Details
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Description
Dofequidar (MS-209) sesquifumarate is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1) . Dofequidar sesquifumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar sesquifumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect[1][2].
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CAS Number
[158681-49-3]
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Molecular Formula
C30H31N3O3.3/2C4H4O4
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Molecular Weight
1311.39
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Smiles
OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC3.O=C(O)/C=C/C(O)=O.[1.5]
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Target
P-glycoprotein
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H361-H412
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Precautions
P264-P270-P273-P280-P330-P405-P501
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Dofequidar (sesquifumarate) [CAS 158681-49-3]
Dofequidar (sesquifumarate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.