DOTA-NI-FAPI-04 [CAS 3078291-78-5]
DOTA-NI-FAPI-04 [CAS 3078291-78-5]
SKU:QM-0009582
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Product Details
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Description
DOTA-NI-FAPI-04 is a FAP inhibitor (IC50 = 7.44 nM) . By integrating FAP targeting with hypoxia-sensitive groups (nitroimidazole), DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes (such as 68Ga and 177Lu) through DOTA to produce radioactive probes ([68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact[1].
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CAS Number
[3078291-78-5]
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Molecular Formula
C51H69F2N15O14
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Molecular Weight
1154.18
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Smiles
O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(N[C@@H](CCC(NCCCN2C=CN=C2[N+]([O-])=O)=O)C(N3CCN(CCCOC4=CC=C(C5=C4)N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)CC3)=O)=O)O
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Target
FAP
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Shipping Conditions
Room temperature
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DOTA-NI-FAPI-04 [CAS 3078291-78-5]
DOTA-NI-FAPI-04 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.