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E 2012 (Standard) [CAS 870843-42-8]
E 2012 (Standard) [CAS 870843-42-8]
SKU:QM-0001704
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Product Details
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Description
E 2012 (Standard) is the analytical standard of E 2012. This product is intended for research and analytical applications. E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat[1].
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CAS Number
[870843-42-8]
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Molecular Formula
C25H26FN3O2
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Molecular Weight
419.49
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Smiles
O=C(N([C@H](C1=CC=C(C=C1)F)C)CCC/2)C2=C\C3=CC=C(N4C=NC(C)=C4)C(OC)=C3
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Target
Reference Standards; γ-secretase
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Shipping Conditions
Room temperature
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E 2012 (Standard) [CAS 870843-42-8]
E 2012 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.