(E) -4-Hydroxycrotonic acid [CAS 24587-49-3]
(E) -4-Hydroxycrotonic acid [CAS 24587-49-3]
SKU:QM-0079860-01
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Product Details
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Description
(E) -4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E) -4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E) -4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
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CAS Number
[24587-49-3]
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Molecular Formula
C4H6O3
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Molecular Weight
102.09
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Smiles
O=C(O)/C=C/CO
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Target
GABA Receptor
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Purity
99.83
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Solubility
DMSO : 175 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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(E) -4-Hydroxycrotonic acid [CAS 24587-49-3]
(E) -4-Hydroxycrotonic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.