(-) - (E) -Guggulsterone (Standard) [CAS 39025-24-6]
(-) - (E) -Guggulsterone (Standard) [CAS 39025-24-6]
SKU:QM-0114541-01
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Product Details
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Description
(-) - (E) -guggulsterone (Standard) is the analytical standard for (-) - (E) -guggulsterone ((E) -Guggulsterone). (-) - (E) -Guggulsterone is an orally active natural stereoisomer of Guggulsterone (HY-107738). (-) - (E) -Guggulsterone is an antagonist for the Farnesoid X Receptor (FXR) with an IC50 of 24.06 μM and possesses potent hypolipidemic properties. (-) - (E) -Guggulsterone suppresses dengue virus (DENV) replication by upregulating antiviral interferon responses by inducing HO-1 expression via Nrf2 activation. (-) - (E) -Guggulsterone exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa. (-) - (E) -Guggulsterone has cardiac protective and antioxidant activities in rats.
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CAS Number
[39025-24-6]
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Molecular Formula
C21H28O2
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Molecular Weight
312.45
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Smiles
C/C=C1C(C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]/12C)=O)=O
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Target
Bacterial; Cytochrome P450; Dengue Virus; Drug Metabolite; Estrogen Receptor/ERR; FXR; Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Reference Standards
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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(-) - (E) -Guggulsterone (Standard) [CAS 39025-24-6]
(-) - (E) -Guggulsterone (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.