(E/Z) -Locostatin [CAS 133812-16-5]
(E/Z) -Locostatin [CAS 133812-16-5]
SKU:QM-0205660-01
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Product Details
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Description
(E/Z) -Locostatin ((E/Z) -UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide -induced acute liver failure in mice[2][3].
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CAS Number
[133812-16-5]
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Molecular Formula
C14H15NO3
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Molecular Weight
245.27
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Smiles
O=C1OC[C@H](CC2=CC=CC=C2)N1C(/C=C/C)=O
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Target
Raf
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Purity
99.52
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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(E/Z) -Locostatin [CAS 133812-16-5]
(E/Z) -Locostatin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.