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Edicotinib (hydrochloride) [CAS 1559069-92-9]

Edicotinib (hydrochloride) [CAS 1559069-92-9]

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SKU:QM-0128245

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  • Description

    Edicotinib hydrochloride is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib hydrochloride exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib hydrochloride limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib hydrochloride has the potential for Alzheimer’s disease and rheumatoid arthritis research[1][2].

  • CAS Number

    [1559069-92-9]

  • Molecular Formula

    C27H36ClN5O2

  • Molecular Weight

    498.06

  • Smiles

    O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2.Cl

  • Target

    C-Fms

  • Shipping Conditions

    Room temperature

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Edicotinib (hydrochloride) [CAS 1559069-92-9]

Edicotinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.