Eeyarestatin I [CAS 412960-54-4]
Eeyarestatin I [CAS 412960-54-4]
SKU:QM-0076113-01
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Product Details
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Description
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects[1][2][3][4][5].
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CAS Number
[412960-54-4]
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Molecular Formula
C27H25Cl2N7O7
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Molecular Weight
630.44
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Smiles
ON(C(C1(C)C)N(C(C=C2)=CC=C2Cl)C(N1CC(N/N=C/C=C/C(O3)=CC=C3[N+]([O-])=O)=O)=O)C(NC(C=C4)=CC=C4Cl)=O
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Target
Apoptosis; p97
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Purity
99.56
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Solubility
DMSO : 25 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Eeyarestatin I [CAS 412960-54-4]
Eeyarestatin I is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.