Efonidipine (hydrochloride monoethanolate) [CAS 111011-76-8]
Efonidipine (hydrochloride monoethanolate) [CAS 111011-76-8]
SKU:QM-0141400-01
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Product Details
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Description
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB) . IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N (6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP) -induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R (-) -efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I (Ca (T) ) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I (Ca (T) ) and L-type Ca2+ channel current (I (Ca (L) ) ) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4]. in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg) . The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3].
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CAS Number
[111011-76-8]
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Molecular Formula
C36H45ClN3O8P
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Molecular Weight
714.18
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Smiles
CC1=C(P2(OCC(C)(C)CO2)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCN(C4=CC=CC=C4)CC5=CC=CC=C5)=O)=C(C)N1.[H]Cl.CCO
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Target
Calcium Channel
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Isoform
L-type calcium channel; T-type calcium channel
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Purity
99.83
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Efonidipine (hydrochloride monoethanolate) [CAS 111011-76-8]
Efonidipine (hydrochloride monoethanolate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.