Egalognastat [CAS 1884154-02-2]
Egalognastat [CAS 1884154-02-2]
SKU:QM-0152033-01
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Product Details
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Description
Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex) . Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) [1].
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CAS Number
[1884154-02-2]
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Molecular Formula
C17H21N5O3S
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Molecular Weight
375.45
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Smiles
CC(NC1=NN=C(N2CCN(CC2)[C@H](C3=CC=C(OCO4)C4=C3)C)S1)=O
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Target
OGA; Tau Protein
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Purity
99.63
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Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Egalognastat [CAS 1884154-02-2]
Egalognastat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.