EGFR/BRAFV600E-IN-5
EGFR/BRAFV600E-IN-5
SKU:QM-0011017
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Product Details
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Description
EGFR/BRAFV600E-IN-5 (Compound 7I) is a dual BRAFV600E/EGFR inhibitor with IC50 of 0.048 μM and 0.037 μM, respectively. EGFR/BRAFV600E-IN-5 has significant anti-melanoma activity with IC50 of 3.16 μM and 2.50 μM against MALME-3M and LOX-IMVI cell lines, respectively. EGFR/BRAFV600E-IN-5 exerts anti-tumor effects by inducing G1 arrest, inhibiting DNA synthesis, and activating the mitochondrial apoptosis pathway. EGFR/BRAFV600E-IN-5 can be used for melanoma research, especially for combined inhibition of BRAFV600E mutation and EGFR signaling pathway[1].
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Molecular Formula
C30H24ClN7O2S2
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Molecular Weight
614.14
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Smiles
O=C(NC1=NC=C(C2=CC=C(Cl)C=C2)S1)CN3N=NC(CSC(N4CC5=CC=CC=C5)=NC6=C(C=CC(C)=C6)C4=O)=C3
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Target
Apoptosis; Bcl-2 Family; EGFR; Raf
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Shipping Conditions
Room temperature
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EGFR/BRAFV600E-IN-5
EGFR/BRAFV600E-IN-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.