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EGFR/CDK2-IN-2
EGFR/CDK2-IN-2
SKU:QM-0072216
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Quantity
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Product Details
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Description
EGFR/CDK2-IN-2 (compound 6a) is a dual inhibitor of EGFR and CDK-2 with IC50s of 19.6 and 87.9 nM, respectively. EGFR/CDK2-IN-2 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-2 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 0.39 μM[1].
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Molecular Formula
C49H32N12O2S2
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Molecular Weight
884.99
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Smiles
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=NN4C(SC3)=NN=C4CC5=NN=C6SCC(C7=NN(C8=CC=CC=C8)C=C7C(C9=CC=C%10C=CC=CC%10=C9)=O)=NN65)C%11=CC=C%12C=CC=CC%12=C%11
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Target
CDK; EGFR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.