EGFR/Cytokine-IN-1
EGFR/Cytokine-IN-1
SKU:QM-0015173
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Product Details
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Description
EGFR/Cytokine-IN-1 is an EGFR (IC50 = 0.03 μM) and Cytokine inhibitor (TNF-α, IC50 = 3.1 μM; IL-6, IC50 = 1.6 ��M) . EGFR/Cytokine-IN-1 shows potent anticancer activity on A549 and MCF7, respectively. EGFR/Cytokine-IN-1 significantly reduces IL-6 and TNF-α levels in A549 cells, and also shows promising ADMET profiles. EGFR/Cytokine-IN-1 can induce apoptosis in a dose-dependent manner. compound 5h can be used for the study of breast cancer and lung cancer[1].
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Molecular Formula
C28H22ClN3O4
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Molecular Weight
499.94
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Smiles
N#CC1=C(C2=C(Cl)C=CC=C2)C=C(C3=CC=C(OC)C=C3)N=C1OCC(NC4=C(OC)C=CC=C4)=O
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Target
Apoptosis; EGFR; Interleukin Related; TNF Receptor
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Shipping Conditions
Room temperature
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EGFR/Cytokine-IN-1
EGFR/Cytokine-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.