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EGFR/DHFR-IN-2
EGFR/DHFR-IN-2
SKU:QM-0011037
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Product Details
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Description
EGFR/DHFR-IN-2 (9b) is a dual h-DHFR/EGFRTK inhibitor, with IC50 values of 0.192 μM and 0.109 μM for h-DHFR and EGFR, respectively. EGFR/DHFR-IN-2 (9b) halts the cell cycle at the G1/S phase and induces apoptosis. EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. EGFR/DHFR-IN-2 (9b) can be used in the cancer research[1].
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Molecular Formula
C24H16N4O5
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Molecular Weight
440.41
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Smiles
CCOC(C1=CC=C(C=C1)N2C(N)=C(C3(C(C#N)=C2O)C(C4=CC=CC=C4C3=O)=O)C#N)=O
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Target
Apoptosis; Cytochrome P450; Dihydrofolate reductase (DHFR) ; EGFR
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Shipping Conditions
Room temperature
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EGFR/DHFR-IN-2
EGFR/DHFR-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.