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EGFR/HER2-IN-11 [CAS 1346176-20-2]
EGFR/HER2-IN-11 [CAS 1346176-20-2]
SKU:QM-0135338
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Product Details
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Description
EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC50s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI50 of 601 nM[1].
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CAS Number
[1346176-20-2]
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Molecular Formula
C23H21ClF3N5O2
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Molecular Weight
491.89
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Smiles
FC(F)(C1=CC(OC2=CC=C(NC3=NC=NC4=C3N(CCNCCO)C=C4)C=C2Cl)=CC=C1)F
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Target
EGFR
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR/HER2-IN-11 [CAS 1346176-20-2]
EGFR/HER2-IN-11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.