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EGFR-IN-1 [CAS 1625677-63-5]
EGFR-IN-1 [CAS 1625677-63-5]
SKU:QM-0074071
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Product Details
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Description
EGFR-IN-1 (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
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CAS Number
[1625677-63-5]
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Molecular Formula
C28H30N6O4
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Molecular Weight
514.58
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Smiles
COC(C=C(OCCN(C)C)C=C1)=C1NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C=C3C)=O)=N2
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR-IN-1 [CAS 1625677-63-5]
EGFR-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.