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EGFR-IN-1 (hydrochloride) [CAS 2227455-78-7]
EGFR-IN-1 (hydrochloride) [CAS 2227455-78-7]
SKU:QM-0155413-01
£539.64 GBP
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Product Details
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Description
EGFR-IN-1 hydrochloride is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 hydrochloride potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
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CAS Number
[2227455-78-7]
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Molecular Formula
C28H31ClN6O4
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Molecular Weight
551.04
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Smiles
COC(C=C(OCCN(C)C)C=C1)=C1NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C=C3C)=O)=N2.[H]Cl
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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EGFR-IN-1 (hydrochloride) [CAS 2227455-78-7]
EGFR-IN-1 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.