EGFR-IN-1 (TFA) [CAS 2753348-63-7]
EGFR-IN-1 (TFA) [CAS 2753348-63-7]
SKU:QM-0155414-01
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Product Details
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Description
EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 TFA displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
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CAS Number
[2753348-63-7]
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Molecular Formula
C30H31F3N6O6
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Molecular Weight
628.6
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Smiles
COC(C=C(OCCN(C)C)C=C1)=C1NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C=C3C)=O)=N2.OC(C(F)(F)F)=O
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Target
EGFR
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Isoform
EGFR/ErbB1/HER1
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Purity
99.38
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Solubility
DMSO : 250 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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EGFR-IN-1 (TFA) [CAS 2753348-63-7]
EGFR-IN-1 (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.