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EGFR-IN-117 [CAS 3035639-05-2]
EGFR-IN-117 [CAS 3035639-05-2]
SKU:QM-0135623
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Product Details
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Description
EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutation, targets the tumor environment, and induces apoptosis of cancer cells. EGFR-IN-117 inhibits proliferations of H1975, PC-9, and EGFR mutant cells BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 of 13 nM, 19 nM, 1.2 nM and 1.3 nM, respectively. EGFR-IN-117 exhibits antitumor efficacy in mouse models[1].
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CAS Number
[3035639-05-2]
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Molecular Formula
C25H30BrN7O2S
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Molecular Weight
572.52
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Smiles
O=S(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCCN(C)CC4)C=C3)=NC=C2Br)(C5CC5)=O
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Target
Apoptosis; EGFR
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Shipping Conditions
Room temperature
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EGFR-IN-117 [CAS 3035639-05-2]
EGFR-IN-117 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.